Fig. 6: CAD contributes to inflammation and immune defense during Influenza A virus infection in mice.
From: The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection
A Changes in body weight in CAD-deficient mice and heterozygous littermates during IAV infection (means/SEM of six mice per group). Statistical analysis was performed using two-way ANOVA, corrected for multiple comparisons by using the Sidak method. B Immune cell-infiltration during IAV-infection as measured in bronchoalveolar lavage fluid (BALF) at 72 hours of IAV infection. BALF cells were analyzed by flow cytometry to identify the populations indicated. Each mouse is shown as one symbol. C Expression of interferon stimulating genes (ISGs) and other pro-inflammatory mediators in murine lung tissues during IAV infection. For B and C, data are means of values from five individual mice per group. Statistical testing was performed using one-way ANOVA, corrected for multiple comparisons by Tukey test. Fold change was calculated after normalizing the values of treatment group with uninfected control group. D, E Viral titers and histopathological score of lung tissues at different time points following viral infection. Mixed-effects model analysis was performed rather than two-way ANOVA due to a missing value in the CAD-/- group at day 5. Data are means of values from five mice. Error bars represent SEM. For all samples: p < 0.05: *, p < 0.01: **, p < 0.001: ***, p < 0.0001: ****.
