Fig. 5: Inhibition of CDK12/13 sensitizes tumour cells to DNA damage induction. | Cell Death & Differentiation

Fig. 5: Inhibition of CDK12/13 sensitizes tumour cells to DNA damage induction.

From: Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system

Fig. 5

Transcriptional activated CDK12/13 guarantee a proper RNAPII elongation rate in a context of MYC-dependent high transcriptional burden, allowing the expression of DDR genes, which in turn ensure tolerance to DNA lesions (upper panel [94]). Simultaneous inhibition of CDK12/13 by THZ531 in Group 3 medulloblastoma cells reduces the transcription of DDR genes, leading to increased sensitivity to DNA damage inducing agents and resulting in cell death (lower panel [39]).

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