Fig. 2: ACBP/DBI deficiency regulated cartilage degradation in osteoarthritis mice.
From: Neutralization of acyl CoA binding protein (ACBP) for the experimental treatment of osteoarthritis
A Representative Safranin O-Fast Green and ACBP/DBI-stained knee sections from wild-type and ACBP/DBI-deficient mice. Scale bar, 200 and 50 μm. B Quantification of ACBP/DBI-positive cells relative to total cells in the medial femoral condyle (MFC) and medial tibial plateau (MTP) was presented. Results are displayed as box-and-whisker plots, with each dot representing an individual mouse (n = 4). For statistical analysis, p values were calculated using two-way ANOVA corrected for multiple comparisons. C OARSI semiquantitative scoring for cartilage degradation (grade), D OARSI semiquantitative scoring for cartilage damage (stage), and E a combined index of grade and stage were used to evaluate the extent of cartilage damage. Results are displayed as box-and-whisker plots, with each dot representing an individual mouse (n = 4–8 mice per condition). For statistical analysis, p values were extracted from 2-way linear models, testing surgery significance within different genotypes (formula: Count ~ Genotype/Surgery) and testing genotype significance within surgery status (formula: Count ~ Surgery/Genotype).
