Fig. 1: NAT10 is increased in adipogenesis.
From: NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis
A Human NAT10 (hNAT10) and mouse NAT10 (mNAT10) were comprehensively distributed in different tissues of human and mice (n = 4 for each). B The hNAT10 mRNA (n = 6) and protein (n = 3). C, D was found increased in SATs and VATs of obese (n = 6) compared to normal weight patients (n = 6). E The mNAT10 mRNA (n = 4) and protein (n = 3) (F, G) was found elevated in eWATs and iWATs of high-fat diet (n = 4) than chew diet mice (n = 4). H, I The mNAT10 protein was gradually increased after mice were fed with high-fat diet for 12 weeks (n = 3). J hNAT10 mRNA expression was upregulated during hADSCs adipogenesis (n = 6). K, L The protein level expression of hNAT10, hFABP4 and hPPARG was upregulated during hADSCs adipogenesis (n = 3). M The TG content was found gradually increased during hADSCs adipogenesis (n = 3). N mNAT10 mRNA (n = 6) and protein expression of mNAT10, mFABP4 and mPPARG (n = 3) (O, P) were upregulated during 3T3-L1 adipogenesis (n = 3). Q The TG content was gradually increased during 3T3-L1 adipogenesis (n = 3). R The protein expression of mNAT10 were comprehensively distributed in mice differential tissues after fed with high-fat diet for 12 weeks (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001.
