Fig. 9: Remodelin decreases adipose tissue expansion in vivo through inhibiting mKLF9 ac4C modification. | Cell Death & Differentiation

Fig. 9: Remodelin decreases adipose tissue expansion in vivo through inhibiting mKLF9 ac4C modification.

From: NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis

Fig. 9

A The protocol of Remodelin gavage in mice. B Food intake in Remodelin and DMSO gavage groups (n = 5). C Body weight in Remodelin and DMSO gavage groups (n = 5). D The mice and eWATs and iWATs photos in Remodelin and DMSO gavage groups. E The weight of iWATs and eWATs (F) in Remodelin and DMSO gavage groups (n = 5). G H&E staining of iWATs in Remodelin and DMSO gavage groups. H The adipocyte size of iWATs in Remodelin and DMSO gavage groups (n = 50). I acRIP-PCR detected mKLF9 (motif 1 and 2) mRNA ac4C level in Remodelin and DMSO gavage groups (n = 4). J–N The mNAT10, mKLF9, mPPARG, CEBPA and FABP4 mRNA expression in Remodelin and DMSO gavage groups (n = 5). O–R The protein expression of mNAT10-mKLF9-mCEBPA/B-mPPARG pathway of iWATs, eWATs and BATs in Remodelin and DMSO gavage groups (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.

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