Fig. 7: DEPTOR disruption induces EGFR levels and activates MAPK and mTORC1/2 pathways in lymphomagenesis.
From: DEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase
A, B DEPTOR disruption induces EGFR levels and activates MAPK and mTORC1/2 pathways. The lymphomas from Deptor+/+;Pten+/− and Deptor−/−;Pten+/− littermate mice were subjected to IHC staining (A) or IB (B) with the indicated Abs. The staining quantification was determined by IHC scoring using an IRS system from three to seven random fields of tissue sections. * p < 0.05; ** p < 0.01. The band density was quantified using ImageJ and expressed as fold change relative to the control, with the control value arbitrarily set to 1. C A model for DEPTOR suppression of lymphomagenesis by promoting HUWE1-mediated EGFR polyubiquitination and proteasomal degradation via binding to HUWE1.
