Fig. 1: Alternative splicing events exhibit distinct alterations across four subgroups of medulloblastoma. | Cell Death & Differentiation

Fig. 1: Alternative splicing events exhibit distinct alterations across four subgroups of medulloblastoma.

From: Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression

Fig. 1

Boxplot of percent sliced in (PSI) values for exons (with ≥10 junction reads) in cerebellum tissue (CTRL) (n = 3) from normal humans and the WNT (a, n = 3), SHH (c, n = 6), G3 (e, n = 9), G4 (g, n = 12) subgroup tumor tissue (MB patients) from medulloblastoma patients (Wilcoxon rank-sum test). Bar chart of percentage of alternative splicing events altered cerebellum tissue (CTRL) from normal humans and the WNT b, SHH d, G3 f, G4 h subgroup tumor tissue (MB patients) from medulloblastoma patients (unpaired t-test). ES Exon-skipping, A5SS Alternative 5′ splice site, A3SS Alternative 3′ splice site, MXE mutually exclusive exon, RI Retained intron. The data are presented as the mean ± SD (bar plots). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. no significant.

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