Fig. 8: Graphic abstract of the role and signaling mechanism of Eftud2 in medulloblastoma progression. | Cell Death & Differentiation

Fig. 8: Graphic abstract of the role and signaling mechanism of Eftud2 in medulloblastoma progression.

From: Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression

Fig. 8

Conditional knockout of Eftud2 in cerebellar granule precursor cells significantly extends survival in SHH medulloblastoma mice, highlighting its critical role in tumor progression. Mechanistically, Eftud2 upregulation promotes medulloblastoma cell proliferation by activating the SHH pathway. This occurs in part through Eftud2-mediated Kif3a exons 10–11 skipping, which enhances Gli2 transcriptional activity and drives oncogenic signaling.

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