Fig. 6: Schematic timeline of putative DAMPs released from ferroptotic cells. | Cell Death & Differentiation

Fig. 6: Schematic timeline of putative DAMPs released from ferroptotic cells.

From: An atlas of ferroptosis-induced secretomes

Fig. 6

Timeline of cell permeabilization, lipid ROS, and the release of factors detected in (1) proteomics, (2) lipidomics, and (3) metabolomics of supernatants from ferroptotic cells. Three stages of ferroptosis can be distinguished: early ferroptosis where cells experience the release of nucleotides such as ATP; intermediate ferroptosis marking the start of lipid ROS detection accompanied by the release of MIF and metabolites involved in the TCA- and methionine cycle, and late ferroptosis with complete permeabilization of the cell with the release of LDH and prostaglandins. All schemes were created with BioRender.com.

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