Fig. 6: GRAMD1A promoted growth and metastasis of CRC in vivo. | Cell Death & Differentiation

Fig. 6: GRAMD1A promoted growth and metastasis of CRC in vivo.

From: KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression

Fig. 6

A Representative images of gross inspection and H&E staining of the CRC orthotopic tumors or liver metastatic tumors (n = 5 per group). Orthotopic tumors scale bar: 0.5 cm; H&E scale bars: 250 μm. B Orthotopic xenograft CRC tumor formation and liver metastasis analysis. C Statistical analysis of orthotopic tumor volumes. D Statistical analysis of number of metastases in H&E staining of liver. E Representative images of gross inspection of subcutaneous xenografts of CRC. Statistical analysis of subcutaneous tumor F volumes and G weights. Values are presented as mean ± SD. *p < 0.05, **p < 0.01, ****p < 0.0001, determined by Mann–Whitney test (C, D, F, G).

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