Fig. 2: Proteomic analysis reveals a crosstalk between Caspase-8 and NRF2. | Cell Death & Differentiation

Fig. 2: Proteomic analysis reveals a crosstalk between Caspase-8 and NRF2.

From: Caspase-8 expression and its Src dependent phosphorylation on Tyrosine 380 triggers NRF2 signaling activation in glioblastoma

Fig. 2

A, B Principal Component Analysis (PCA) of the analytes quantified across proteome (A) and phosphoproteome (B) replicates. C Barplot reporting the number of significantly modulated proteins and phosphosites in shC8 compared to shCTR cells. D Heatmap of protein abundance of the NRF2 targets quantified. E, F Bar plots reporting the GO-biological processes and KEGG pathways enriched by the proteins that are significantly downregulated (E) or upregulated (F) in shC8 compared to shCTR cells. G Box plot of modulated proteins involved in specific metabolic pathways reported as the median log2 fold change in shC8 cells vs shCTR cells. H The phosphorylation intensity was normalized on the total median intensity of all the quantified phosphosites in each experimental condition. Then the normalized intensity of the significantly modulated mTOR substrates between shC8 and shCTR cells was reported in the violin plot.

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