Fig. 5: Lactylation of histone H4K12 promotes polarization of macrophages towards the M2 phenotype.

A The number of lactylation modification sites and proteins, as well as the quantity change between presence and absence of lactylation modification in M1 or M1 treated with 10 mM lactate for 48 h. B Changes in histone modification sites and their intensity between the two groups. C Western blotting showing the H4K12La in the two groups. D Western blotting showing the H4K12La in the macrophages in peripheral blood of the healthy people and CKD patients.