Fig. 2: CCDC719-13 inhibits prostate cancer cell proliferation and promotes apoptosis in vitro and suppresses tumor growth in vivo. | Cell Death & Differentiation

Fig. 2: CCDC719-13 inhibits prostate cancer cell proliferation and promotes apoptosis in vitro and suppresses tumor growth in vivo.

From: Induction of ferroptosis in prostate cancer by CCDC719-13 via TRIM21-mediated ubiquitination of SLC7A11

Fig. 2

A Relative expression of CCDC719-13 in PC3 and DU145 cells transfected with scramble control, CCDC719-13 overexpression vector, or CCDC719-13 overexpression combined with specific siRNAs. Cell viability of B PC3 and C DU145 cells with the same transfections. D Colony formation assay in PC3 and DU145 cells after the indicated transfections. Colonies were stained with crystal violet. E Quantification of colony numbers from (D). F Flow cytometry scatter plots showing apoptosis in PC3 and DU145 cells after transfections. G Quantification of apoptotic cells from (F). H Bioluminescence images of PC3 xenografts in BALB/c mice injected with cells transfected as indicated. I Quantification of bioluminescence intensity from (H). Data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.

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