Fig. 5: Alt-NHEJ components are upregulated in NCSC-derived solid tumors. Immunohistochemical analysis was performed on sections of tumors generated from NCSC-MYCN xenografts | Cell Death & Disease

Fig. 5: Alt-NHEJ components are upregulated in NCSC-derived solid tumors. Immunohistochemical analysis was performed on sections of tumors generated from NCSC-MYCN xenografts

From: Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation

Fig. 5

a Tumor specimen from IMR32 NBL xenografts (upper left panel) were utilized as positive controls for Lig3. NCSC-MYCN tumors had diffuse nuclear and cytoplasmic labeling in tumor sections with minimal to mild nuclear expression in adjacent tissues. b Positive control IMR32 NBL xenograft tumor (upper left panel) and NCSC-MYCN tumor with diffuse nuclear labeling of PARP1. c NCSC-MYCN tumor with strong and diffuse PARP1 labeling with adjacent kidney tissue deficient in PARP1 expression

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