Fig. 4: Silencing hippocampal RIP140 rescues As-suppressed hippocampus-dependent learning ability | Cell Death & Disease

Fig. 4: Silencing hippocampal RIP140 rescues As-suppressed hippocampus-dependent learning ability

From: Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response

Fig. 4

a Adult male mice injected, intra-hippocampally, with lentivirus (empty vector or shRRIP140) were allowed to recover for 1 week, and received As 100 μg/L in drinking water for 4 weeks. Mice performance in the Barnes maze test and then rotarod test are monitored. b Chronic As treatment affects learning performance, but not travel speed monitored in Barnes maze test (Lenti-CON, N = 10; Lenti-CON + As, N = 11; Lenti-shRIP+ As, N = 11). The deficit is rescued by silencing hippocampal RIP140. c Chronic As treatment or RIP140 knockdown has no significant effect on memory function monitored in Barnes maze test. d Chronic As treatment or RIP140 knockdown has no significant effect on motor skill learning monitored in rotarod test (Lenti-CON, N = 8; Lenti-CON + As, N = 11; Lenti-shRIP + As, N = 10). e Effects of chronic As treatment or RIP140 knockdown on hippocampal RIP140 and HSP70 mRNA expression (N = 4). Results are presented as means ± SEM, *p < 0.05, **p < 0.01 comparing Lenti-CON and Lenti-CON + As, # p < 0.05 comparing Lenti-CON + As and Lenti-shRIP + As. Statistical analyses performed by two-way repeated measure ANOVA with Bonferroni’s post hoc test

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