Fig. 6: RIP140 attenuates HSR via association with HSF1 | Cell Death & Disease

Fig. 6: RIP140 attenuates HSR via association with HSF1

From: Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response

Fig. 6

a, b HSF1 translocation to the nucleus after 1 h As treatment in HT22 cells. c Immunoprecipitation showing RIP140 associated with HSF1 in HT22 after As treatment. d In situ proximal ligation assay showing increased association of RIP140 with HSF1 after As treatment (N = 10/group). e Diagram showing heat shock element (HSE) and non-sense segment (NS) on the promoter of iHSP70. ChIP showing enhanced chromatin binding of RIP140 and HSF1 after As treatment (N = 3 with two repeated tests). Results are presented as means ± SEM, **p < 0.01 compared with the control group by independent t-test

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