Fig. 1: miR-181a-5p expression in human placentas and human trophoblast cells
From: miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2
a Differential miR-181a-5p expression in severe pre-eclamptic placentas (n = 10) and normal placentas (n = 10) was assessed by qRT-PCR. b miR-181a-5p expression in three trophoblast cell lines, with the highest expression observed in JEG-3 cells and the lowest expression observed in HTR-8/SVneo cells. c Invasion and migration capacities of the three tested trophoblast cell lines. JEG-3 cells had significantly lower invasion/migration capacities than HTR-8/SVneo and JAR cells. Representative fields of invaded/migrated cells (at 200× original magnification, bar = 10 μm) are shown. #The JEG-3 cells applied in invasion/migration assays were two-fold more than HTR-8/SVneo and JAR cells, as its weak invasion/migration capacities. The results are expressed as the mean ± SD based on at least three independent experiments. **P < 0.01; the values with diverse letters are also significantly different (P < 0.01)
