Fig. 1: PNPO expression in human ovarian tissues | Cell Death & Disease

Fig. 1: PNPO expression in human ovarian tissues

From: Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer

Fig. 1

a Immunohistochemistry staining of PNPO. Representative images of PNPO expression in the normal tissues of the fallopian tube and the ovary, serous and mucinous benign, borderline and malignant tumours, and endometrioid, clear cell and transitional cell malignant tumours are shown. A brown colour in an epithelial cell is considered as a positive staining. Original magnification, ×400. Scale bar, 50 µm. b Positive rate of PNPO protein expression in patients with ovarian tumours. Epithelial, surface epithelial-stromal tumours; Sex cord, sex cord-stromal tumours; Germ cell, germ cell tumours. c PNPO mRNA expression detected by qRT-PCR in the normal ovarian tissues, ovarian serous benign, borderline and malignant tumours (n = 3 each). d PNPO protein expression detected by western blot analysis in normal ovarian tissue (#1–3), ovarian serous benign tumours (#4–6), borderline tumours (#7–9) and malignant (#10–12) tumours. e Semi-quantitative analysis of the relative optical density of protein bands in d. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01

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