Fig. 4: Candidate transcription factors of the miR-221-3p promoter are identified | Cell Death & Disease

Fig. 4: Candidate transcription factors of the miR-221-3p promoter are identified

From: RETRACTED ARTICLE: MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2

Fig. 4

a Bioinformatic prediction and screening of potential transcription factors of miR-221-3p. b Correlation analysis of TWIST2 and miR-221-3p expression detected by qRT-PCR in 28 additional SCC tissues. The expression levels of TWIST2 were plotted against the expression levels of miR-221-3p. c The certified result of microarray analysis. Hierarchical clustering of eight significantly dysregulated miRNAs expression profiles of the three groups, including SiHa, SiHa-shtw2, and SiHa-tw2 cells. d qRT-PCR analysis of the eight significantly dysregulated miRNAs expressed in SiHa, SiHa-shtw2, and SiHa-tw2 cells, and in HeLa cells transfected with TWIST2 expression vector or TWIST2 siRNA. MiR-221-3p emerged as a highly upregulated miRNA. Data represent means ± SD of five randomly selected areas (*p < 0.05)

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