Fig. 4: Identification of novel miR-663 target genes | Cell Death & Disease

Fig. 4: Identification of novel miR-663 target genes

From: miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2

Fig. 4

a Unsupervised hierarchical clustering of genes that are significantly upmodulated upon miR-663 depletion (≥1.5 fold increase); genes in the heatmap are shown starting from the most upregulated to the most downmodulated one. The top 50 genes are shown. The arrow indicates BTG2 and the star CDKN1A/p21. b Venn diagram showing the integrated analysis of putative miR-663 target genes and top 568 upregulated genes ( > 1.5 fold) upon miR-663 knock down. Twenty-six identified putative target genes of miR-663 are listed in the table together with relative fold increase as measured by gene arrays

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