Table 1 Chemoresistance-related genes regulated by ZEB1
From: ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM
Gene | Fold-enrichment | Chromosome | Distance to TSS | ZEB1 consensus site | Validated by ChIP-PCR | Function | Reference(s) | mRNA correlation with ZEB1 in TCGA database |
|---|---|---|---|---|---|---|---|---|
ATM | 6.88 | chr11:108108119–108108633 | −849 | CAGGTG | YES | Cell cycle checkpoint signaling pathways, DNA damage repair | Huizhen Sun et al., 2014 | 0.48 |
NLGN1 | 5.92 | chr3:173601748–173602302 | −184 | CAGGTG | YES | Act as splicesite-specific ligands for beta-neurexins | Ben Davidson et al., 2014 | 0.38 |
CLASP1 | 8.67 | chr2:122288282–122289026 | 2560 | CAGGTG | YES | Regulation of microtubule dynamics | Katarzyna et al., 2014 | 0.29 |
CD4 | 8.11 | chr12:6944779–6945395 | −569 | CAGGTG | YES | Initiate or augment the early phase of T-cell activation | Jee-eun kim et al., 2014 | 0.29 |
RPS6KB1 | 6.98 | chr17:58045197–58045894 | 469 | CAGGTG | YES | mTOR signaling pathway | Jun He et al., 2015 | 0.22 |
BIRC3 | 6.98 | chr11:102191447–102191786 | 133 | CAGGTG | YES | Inhibit apoptosis by binding toTRAF1 and TRAF2 | Xu Chen et al., 2015 | 0.16 |
PIM3 | 8.67 | chr22:50364008–50364825 | −401 | CAGGTG | YES | Cell proliferation and survival, coexpression with MYC | Dapeng Xu et al., 2013 | −0.30 |
KIF2C | 4.74 | chr1:45186733–45187724 | −507 | CAGGTG | NO | Microtubule-dependent molecular motors | Fung Zhao et al., 2014 | −0.37 |
SLC3A2 | 10.31 | chr11:62608316–62609696 | 1347 | CAGGTG | NO | Regulation of intracellular calcium levels, transports L-type amino acids | Zunyan Dai et al., 2007 | −0.40 |
