Table 1 The relationship between PLK4 expression and clinical pathological characteristics in 85 NB patients

From: Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

Characteristics

Cases, n

PLK4

χ2

P-value

  

Lower, n

Higher, n

  

Sex

  Male

52

31

21

0.035

0.515

  Female

33

19

14

  

Age

  <18 months

14

10

4a

1.099

0.228

  ≥18 months

71

40

31

  

Primary site

  Abdomen, cervix

69

37

32

4.093

0.038*

  Pelvis, thorax

16

13

3a

  

N-myc status

  Amplification

25

16

9

0.037

0.528

  Unamplification

47

29

18

  

Serum LDH level

  <1500 U/L

59

46

13

29.181

<0.001***

  ≥1500 U/L

26

4 a

22

  

Bone marrow metastasis

  Positive

62

33

29

2.964

0.069

  Negative

23

17

6

  

Recurrence

  Yes

41

18

23

7.280

0.006**

  No

44

32

12

  

Expression level of Ki-67

  Low

40

29

11

5.835

0.016*

  High

45

21

24

  

Clinical stage of INSS

  1, 2, 4s

11

10

1a

5.270

0.019

  3, 4

74

40

34

  
  1. LDH lactate dehydrogenase, INSS International Neuroblastoma Staging System
  2. *P   < 0.05, **P  <  0.01, ***P < 0.001
  3. aFisher test was used when n < 5
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