Fig. 3: Effect of US31 expression on cellular function of monocytes/macrophages | Cell Death & Disease

Fig. 3: Effect of US31 expression on cellular function of monocytes/macrophages

From: The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation

Fig. 3

The most significant GO Process, Process Network, and Disease (by Biomarkers) terms for the differentially expressed genes detected in our RNA-Seq analysis of Ad-US31-infected THP-1 cells a and THP-1-derived macrophages b. The terms were filtered in accordance with P < 0.05 and FDR < 0.05. The top 10 significantly enriched terms are shown (software from Thomson Reuters Corporation was used to analyze differentially expressed genes). c A total of 16 of the M1-associated genes are upregulated in THP1 and THP-1-derived macrophages following infection with Ad-US31 (Fold change > 1.5 except IL15RA is 1.4 in THP-1-derived macrophage)

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