Fig. 6: Eltrombopag does not improve the colony-forming potential of SAA-iPSC-derived-hematopoietic progenitors | Cell Death & Disease

Fig. 6: Eltrombopag does not improve the colony-forming potential of SAA-iPSC-derived-hematopoietic progenitors

From: iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors

Fig. 6

a Schematic of the experimental design used to analyze the effect of eltrombopag on the colony-forming potential, proliferation and DNA repair capacity in SAA-iPSC based hematopoietic progenitors; b–d Analysis of CFUs generated in DMSO (dark blue bars) and eltrombopag-treated (orange bars) iPSC-derived-hematopoietic progenitors in WT and SAA cell lines in non-replicative stress conditions; b Total CFUs, c erythroid-lineage CFUs, d myeloid-lineage CFUs. e–g Analysis of CFUs generated in DMSO (red bars) and eltrombopag-treated (grey bars) iPSC-derived-hematopoietic progenitors in WT and SAA cell lines under replicative stress conditions: e Total CFUs, f erythroid-lineage CFUs, g myeloid-lineage CFUs. b–g Multiple t-test using Holm-Sidak method was used for statistical comparison between DMSO and eltrombopag groups. Data is presented as mean of at least 3 independent experiments ± S.E.M. Data for all control cell lines is averaged in one group (WT)

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