Table 1 Subsets and effectors of Breg
From: Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation
Subsets | Mouse | Human | Effector | Different mechanisms should be seperated by ENTER or semicolon. | Reference |
|---|---|---|---|---|---|
Transitional 2 marginal zone precursor B cells/marginal zone precursor B cells | CD21hiCD23+CD24hiIgMhiIgD+CD1d+ | CD23+sIgMhisIgD+CD21/CD35hi | IL-10 | Suppress Th1/17 and T-cell proliferation (add ENTER or ";")Induce Tr1/Treg cells | |
Marginal zone B cells | CD19+CD23-CD21+ | – | IL-10 | Suppress antigen-specific CD8+ T-cell and CD4+ T-cell response add ENTER or ";"Induce Tr1 cells | |
Peritoneal B1a B cells | CD19+CD5+CD11b+ | – | IL-10 | Regulate neutrophil infiltration (add ENTER or ";") Suppress CD4+ T-cell activation and pro-inflammatory cytokine production | |
Plasma cells/plasmablasts | CD138+/hiCD22- | CD27intCD38+ | IL-35, IL-10, Blimp1, IRF4 | Inhibit Th1/17, neutrophils, natural killer cells and dendritic cells (add ENTER or ";") Regulate B cells antigen-presenting ability and pro-inflammatory cytokine secretion (add ENTER or ";")Induce IL-10-producing B cells and IL-35-producing B cells | |
B10 | CD5+CD1dhi | CD5+CD1dhi, CD24hiCD27+ | IL-10 | Suppress CD4+ T cells proliferation and pro-inflammatory cytokine secretion (add ENTER or ";") Suppress antigen-presenting function of dendritic cells Regulate monocyte cytokine production | |
TIM-1+ B cells | CD19+TIM-1+ | CD19+TIM-1+ | IL-4, IL-10 | Promote Th2 response (add ENTER or ";") Suppress Th1/17(add ENTER or ";") Suppress antibodies secreted by plasma cells | |
Naive B cells/transitional B cells | – | CD19+CD24+/hiCD38hi | IL-10, TGF-β | Suppress IFN-α production by plasmacytoid dendritic cellsadd (ENTER or ";") Suppress T-cell proliferation, inhibit Th1/17 Induce Tregs and Tr1 cells | |
Circulating B cells | – | CD19+CD25hi CD27hiCD1dhi CD86hi | IL-10, TGF-β | Suppress T-cell proliferation (add ENTER or ";") Induce Tregs |
