Fig. 2: Roy-Bz selectively translocates PKCδ to the perinuclear region in human tumor cells | Cell Death & Disease

Fig. 2: Roy-Bz selectively translocates PKCδ to the perinuclear region in human tumor cells

From: Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy

Fig. 2

HCT116 cells transfected with pEGFP-N1-PKCα, pEGFP-N1-PKCδ, or pEGFP-N1-PKCε were treated with PMA, Roy-Bz, or vehicle for 1 h; PKC localization was determined by confocal microscopy. a Images are representative of three independent experiments; scale bar = 10 µm and magnification = ×100. b Quantification of cells with PKC translocation; data are mean ± SEM of three independent experiments; values significantly different are indicated (***p < 0.001), unpaired Student’s t-test

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