Table 1 Toxicity studies of Roy-Bz in Wistar rats

	Saline	Vehicle	Treated
Body weight and relative tissue weight (trophism)
BW (g)	340.30 ± 13.45	361.80 ± 0.01	308.25 ± 10.51
Heart/BW (g/kg)	3.03 ± 0.03	3.01 ± 0.09	3.33 ± 0.21
Liver/BW (g/kg)	38.71 ± 2,36	38.52 ± 0.89	42.06 ± 0.98
Kidney/BW (g/kg)	7.08 ± 0.40	6.81 ± 0.27	8.07 ± 0.31
Spleen (g/kg)	2.10 ± 0.20	2.15 ± 0.12	2.93 ± 0.14
Biochemical data
Blood glucose(mg/dL)	188.00 ± 7.51	207.20 ± 7.00	155.00 ± 22.67
Urea (mg/dL)	20.67 ± 0.77	18.34 ± 0.24*	17.95 ± 0.59
Uric acid (mg/dL)	1.07 ± 0.07	0.82 ± 0.10	2.08 ± 0.45^#
Creatinine (mg/dL)	0.30 ± 0.00	0.30 ± 0.01	0.29 ± 0.01
Total proteins (g/dL)	5.50 ± 0.00	5.35 ± 0.17	6.30 ± 0.11^#
Albumin (g/dL)	3.03 ± 0.03	2.90 ± 0.05	3.13 ± 0.10
ALT (U/L)	36.00 ± 2.89	30.75 ± 3.30	45.75 ± 10.29
AST (U/L)	95.33 ± 25.36	56.25 ± 4.60	125.67 ± 41.79
Total chol (mg/dL)	44.33 ± 1.76	52.40 ± 3.54	67.00 ± 6.10
Triglycerides (mg/dL)	107.00 ± 16.29	161.40 ± 17.55	137.00 ± 0.07
Hematological data
RBC count (×10⁶/µL)	7.10 ± 0.15	7.41 ± 0.28	7.84 ± 0.30
HGB (g/dL)	13.97 ± 0.18	13.95 ± 0.46	13.48 ± 0.54
HCT (%)	40.50 ± 0.82	42.28 ± 2.03	43.33 ± 1.89
WBC counts (×10³/µL)	1.93 ± 0.68	2.15 ± 0.88	1.55 ± 0.49
PLT counts (×10³/µL)	811.00 ± 29.61	793.80 ± 28.35	913.25 ± 81.96
RET counts (%)	2.80 ± 0.12	3.56 ± 0.23	4.65 ± 0.33

Data were analyzed for saline, vehicle and 10 mg/kg Roy-Bz (treated) rat groups, after four intraperitoneal administrations (twice a week). Results are mean ± SEM of four independent experiments
ALT alanine aminotransferase, AST aspartateaminotransferase, BW body weight, CK creatine kinase, HCT hematocrit, HGB hemoglobin concentration, PCT plateletcrit, PLT platelet, RBC red blood cell count, RET reticulocytes, WBC white blood cells
*p < 0.05 (comparison between saline and vehicle groups; control groups)
^#p < 0.05 (comparison between Roy-Bz and control groups), and between vehicle and treated groups)

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