Fig. 5: AEAC enhances the effect of doxorubicin on suppressing tumor growth, which leads to an increase in the survival of tumor-bearing animals | Cell Death & Disease

Fig. 5: AEAC enhances the effect of doxorubicin on suppressing tumor growth, which leads to an increase in the survival of tumor-bearing animals

From: Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

Fig. 5

a Tumor volume and b life span of tumor-bearing mice were estimated. C57/Bl6 mice were inoculated subcutaneously with 106 B16 cells. Seven days later, doxorubicin or AEAC alone or in combination in DMSO was applied every two days to the injection area; c C6 glioma cells were grafted intracranially, and seven days later rats were injected intraperitoneally with doxorubicin or AEAC alone or in combination. The therapy continued to day 27 after grafting, and application was repeated each second day. The cumulative proportion surviving Kaplan–Meier curve is presented. Statistical significance is indicated as ** p < 0,0.1

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