Fig. 4: ZAK overexpression is significantly associated with poor prognosis
From: Mixed lineage kinase ZAK promotes epithelial–mesenchymal transition in cancer progression
a Comparison of ZAK mRNA expression between altered group and unaltered group in two TCGA datasets. b Kaplan-Meier survival curves depending on ZAK mRNA alterations in above TCGA datasets. All plots and statistical analyses in (a, b) were obtained from cBioPortal TCGA database (www.cbioportal.org) in August, 2016. More datasets are shown in Supplementary Figures S6. c Breast invasive carcinoma samples in the TMA were immunostained with an anti-ZAK antibody. Representative ZAK-positive and ZAK-negative samples are shown. Scale bars = 50 μm. d Kaplan–Meier curves for overall survival differences between ZAK-positive and ZAK-negative groups. e Combination of ZAK with clinicopathological parameters results in more accurate stratification and prognosis of breast invasive cancer cases in the TMA dataset. Kaplan–Meier overall survival curves on individual clinicopathological parameters (top), and in combinations with ZAK (bottom). The P-value was calculated using the Log-rank test. AUCs obtained from ROC analysis represented the prognostic accuracy. Additional data related to Fig. 4 are in Supplementary Figures S5, S6, and S7
