Fig. 5: HBP1 promotes NPC cell invasion in vitro | Cell Death & Disease

Fig. 5: HBP1 promotes NPC cell invasion in vitro

From: HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma

Fig. 5

a Re-expression of miR-29c inhibited HK1, HNE1, and CNE2 cells invasion in vitro as measured by trans-well assay. Right panel: Statistical analysis for the invaded cells, ***p < 0.001. Scale bars, 100 μm. b HBP1 knockdown inhibited HNE1 and CNE2 cells invasion in vitro as measured by a trans-well assay. Right panel: Statistical analysis for the invaded cells. p = 0.0095 and p < 0.0001. Scale bars, 100 μm. c Western blotting for invasion-associated molecules (N-cadherin, Vimentin, and β-catenin) and inhibitory molecules (ZO-1 and E-cadherin) in HK1, HNE1, and CNE2 cells after transfection with miR-29c mimics or NC. d Western blotting for invasion-associated molecules (N-cadherin, Vimentin, β-catenin, MMP9, NF-κB) and inhibitory molecules (ZO-1 and E-cadherin) in HNE1 and CNE2 cells after transfection with siHBP1 or siNC

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