Fig. 8: HBP1 knockdown blocks NPC xenograft growth and metastasis in vivo | Cell Death & Disease

Fig. 8: HBP1 knockdown blocks NPC xenograft growth and metastasis in vivo

From: HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma

Fig. 8

a Xenograft tumors in nude mice injected with miR-29c agomir or NC agomir were removed (31 days) after their initial transplantation in HK1 cells. Scale bars, 0031 cm. b Tumor volume curve for HK1 cells transplanted into nude mice with miR-29c or NC agomir therapy. (p = 0.0019). c Paraffin sections were stained with H & E and in situ hybridization for detecting miR-29c expression levels. Immunohistochemistry for HBP1 and Ki67 protein levels in miR-29c agomir or NC agomir-treated group tumor tissues. Scale bars, 100 μm. d Tumor growth observed over time showed a reduction in the group with siHBP1 treatment compared with NC treatment. Scale bars, 1 cm. e Top panel: Tumor growth curve of xenografts in nude mice as above (d), p < 0.001. Bottom panel: Tumor weight of xenografts in nude mice as above d, p = 0.0081. f Metastasis in the lungs from tumor-bearing nude mice treated with siHBP1 or NC. Scale bar, 1 cm. g Statistical analysis for the metastatic nodes in nude mice as above (f). h H & E and immunohistochemistry analysis for paraffin sections of nude mice from tumor xenografts. i H & E staining for paraffin sections from nude mice lungs tissues. Scale bars, 200 μm, 100 μm and 50 μm, respectively

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