Fig. 5: circHIPK3 regulated the proliferation and migration of HCC cells via the miR-124-AQP3 axis. | Cell Death & Disease

Fig. 5: circHIPK3 regulated the proliferation and migration of HCC cells via the miR-124-AQP3 axis.

From: circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma

Fig. 5

a Knockdown efficacy of circHIPK3 and HIPK3 mRNA in Huh7 and MHCC-LM3 cells was determined by qRT-PCR, respectively. b The effects of circHIPK3 and HIPK3 mRNA knockdown on Huh7 and MHCC-LM3 cells by CCK-8 assay. (c) circHIPK3 knockdown suppressed the migration of Huh7 and MHCC-LM3 cells. d, e circHIPK3 knockdown decreased AQP3 mRNA and protein expression in Huh7 and MHCC-LM3 cells. f, g miR-124 inhibitor rescued si-circHIPK3-induced reduction of the proliferation and migration in both Huh7 and MHCC-LM3 cells. h Reduction of AQP3 induced by si-circHIPK3 could be rescued by miR-124 inhibition. Error bars represent mean ± SD from three independent experiments. *p < 0.05; ns: no significance

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