Fig. 6: Knockdown of circHIPK3 suppressed tumor growth in vivo.

a The xenograft tumors were significantly depressed by circHIPK3 depletion. b, c Tumor volume and tumor weight of the xenografts were remarkably inhibited by sh-circHIPK3. d circHIPK3 depletion downregulated AQP3 expression in vivo by western blot analysis. e The expressions of AQP3 and Ki67 in the xenograft tumors were examined by IHC. Error bars represent mean ± SD from three independent experiments. *p < 0.05