Table 1 Correlations between the clinical pathological features and expressions of miR-124, AQP3, circHIPK3, and mRNA of HIPK3

Parameter		miR-124 expression		p-value	AQP3 expression		p-value	circHIPK3 expression		p-value	mHIPK3 expression		p-value
	n	T > N (14)	T < N (36)		T > N (41)	T < N (9)		T > N (41)	T < N (9)		T > N (42)	T < N (8)
Age (year)
<60	32	11	21	0.181	24	8	0.182	26	6	1	26	6	0.76
≥60	18	3	15		17	1		15	3		16	2
Sex
Male	38	13	25	0.17	31	7	1	31	7	1	30	8	0.173
Female	12	1	11		10	2		10	2		12	0
Tumor size (cm)
≤5	20	3	17	0.095	18	2	0.409	18	2	0.409	18	2	0.581
>5	30	11	19		23	7		23	7		24	6
Differentiation grade
Well-moderate	23	6	17	0.781	22	1	0.028*	22	1	0.028*	20	3	0.883
Poor-undifferentiation	27	8	19		19	8		19	8		22	5
TNM stage
I–II	20	11	9	0.01*	13	7	0.029*	13	7	0.029*	14	6	0.07
III–IV	30	3	27		28	2		28	2		28	2
HBsAg
Negative	9	1	8	0.403	9	0	0.183	8	1	0.908	8	1	1
Positive	41	13	28		32	9		33	8		34	7
HBV-DNA
≥10³/copies	23	6	17	0.781	18	5	0.79	15	8	0.013*	18	5	0.526
<10³/copies	27	8	19		23	4		26	1		24	3
Cirrhosis
Negative	16	11	5	<0.001*	10	6	0.039*	9	7	0.04*	10	6	0.015*
Positive	34	3	31		31	3		32	2		32	2
GVI
Negative	43	10	33	0.162	38	5	0.017*	35	8	1	37	6	0.673
Positive	7	4	3		3	4		6	1		5	2
BCLC stage
A–B	42	9	33	0.024*	38	4	0.02*	35	7	0.952	36	6	0.817
C–D	8	5	3		3	5		6	2		6	2

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