Fig. 2: Knockdown of OPN inhibits ICC growth and metastasis in vitro. | Cell Death & Disease

Fig. 2: Knockdown of OPN inhibits ICC growth and metastasis in vitro.

From: Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin

Fig. 2

Knockdown of OPN significantly inhibited the a proliferation, b colony formation, c wound healing, d migration, and e invasion of HuCCT1 (left) and CCLP1 (right) cells, which were restored by shOPN-3-resistant OPN (shRES). Scr scrambled shRNA. All assays were performed in triplicate wells and repeated three times for each cell line, scale bar = 200 μm

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