Fig. 5: Prediction of miR-328-5p-mediated signaling pathways and function annotations for miR-328-5p. | Cell Death & Disease

Fig. 5: Prediction of miR-328-5p-mediated signaling pathways and function annotations for miR-328-5p.

From: Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

Fig. 5

a The Venn diagram indicates the relevant pathways mediated by miR-328-5p. ErbB pathway was intersected predicted by three different databases. b DAVID function annotation for the miR-328-5p targeted genes of the ErbB pathways. The vertical axis shows the annotated functions of the target genes. The horizontal axis shows the gene number of each cluster respectively. The color indicated the −log10 transformed P value of each GO term. c Mapping of ErbB pathway mediated by miR-328-5p. In this map, circ-GRB10 could act as positive regulators of target genes, while miR-328-5p function as negative regulators. The yellow target genes could be regulated by the circ-GRB10/miR-328-5p axes to devote to the initiation and progression of IDD. d, e Expression of ERBB2 in IDD NP tissues, showing that ERBB2 expression was significantly lower than that of controls both at the mRNA d and protein e levels. **P < 0.01, n = 3

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