Fig. 1: B4GalT5 expression is positively correlated with type 2 diabetes and obesity. | Cell Death & Disease

Fig. 1: B4GalT5 expression is positively correlated with type 2 diabetes and obesity.

From: Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation

Fig. 1

a B4GalT5 expression in subcutaneous adipose tissue from subjects with neither obesity nor diabetes (n = 12) vs. those without obesity but with diabetes (n = 9); and from subjects with obesity but without diabetes (n = 6) vs. with both obesity and diabetes (n = 13). b Correlation analysis between BMI and B4GalT5 mRNA levels in subcutaneous adipose tissue of human (n = 52). c–d qPCR analysis of B4GalT5 mRNA expression and western blotting detect B4GalT5 protein level in inguinal (subcutaneous) adipose tissue of C57BL/6 J mice fed with ND or HFD for 12 weeks (n = 14), and ob/ob mice (n = 8) and their wild-type(WT) littermates (n = 8). e B4GalT5 mRNA expression in stromal vascular fraction (SVF) or mature adipocytes fraction (AD) isolated from inguinal adipose tissue of C57BL/6 J mice fed with HFD for 12 weeks (n = 6). f The relative mean fluorescence intensity (MFI) by flow cytometric analysis of SVF and AD for B4GalT5 expression in inguinal adipose tissue of C57BL/6 J mice fed with HFD for 12 weeks (n = 6). Statistical analysis was performed by collating the results from multiple samples. *P < 0.05, **P < 0.01, ***P < 0.001

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