Fig. 7: Working model. | Cell Death & Disease

Fig. 7: Working model.

From: KRAS induces lung tumorigenesis through microRNAs modulation

Fig. 7

KRAS, through the transcription factor ELK1, activates miR-30c and miR-21, which in turn, by downregulating NF1, RASA1, RASSF8, and BID, regulates KRAS, NF-kB, and the intrinsic apoptotic pathways, inducing lung tumorigenesis and inhibiting apoptosis in NSCLC. MiR-30c and miR-21 are released into the bloodstream and could be potential biomarkers for early NSCLC detection

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