Fig. 3: PANDAR regulated CDKN1A gene expression.

a Venn diagrams show the number of differentially expressed genes from the PANDAR-depleted AGS cells and PANDAR-overexpressed AGS cells, and gene ontology showed the associated cellular pathways with these candidates. b QRT-PCR analysis determined the expression of putative PANDAR targets in PANDAR knockout AGS cells (PANDAR−/−). c The location of PANDAR. U2 RNA was used as a positive control for nuclear RNA. d Immunoblotting analysis determined the expression of p21 protein in cancer cells treated with dose-gradient increased PANDAR