Fig. 5: Tan IIA synergistically enhanced the anti-proliferative activity of 17-AAG and ganetespib. | Cell Death & Disease

Fig. 5: Tan IIA synergistically enhanced the anti-proliferative activity of 17-AAG and ganetespib.

From: The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG

Fig. 5

a MCF-7 cells were exposed to 17-AAG at the specified concentrations for 24 h in the presence or absence of Tan IIA (0.5, 1, 5, and 10 μM, respectively). Cell viability was determined by the CCK-8 method. b The CI (combination index) values for Tan IIA and 17-AAG combinations. c MCF-7 cells were exposed to ganetespib at the specified concentrations for 24 h in the presence or absence of Tan IIA (0.5, 1, 5, and 10 μM, respectively). d The CI values for Tan IIA and ganetespib combinations by treating cells for 24 h. e MCF-7 cells were exposed to ganetespib at the specified concentrations for 48 h in the presence or absence of Tan IIA (0.5, 1, 5, and 10 μM, respectively). f The CI values for Tan IIA and ganetespib combinations by treating cells for 48 h. All the data presented as inhibition rate of the untreated control (mean ± S.D. of three independent experiments). *p < 0.05 and **p < 0.01 when compared to the corresponding 17-AAG or ganetespib treatment in the absence of Tan IIA

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