Fig. 7: CaM suppression inhibited activity of Src and MMPs and downregulated vimentin expression. | Cell Death & Disease

Fig. 7: CaM suppression inhibited activity of Src and MMPs and downregulated vimentin expression.

From: The interactome and spatial redistribution feature of Ca2+ receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion

Fig. 7

a Using W7 and CaM knockdown both significantly inhibited phosphorylation level of Src. b Using W7 and CaM knockdown abolished EGF-induced Src phosphorylation. c Using W7 (10 μm) and CaM knockdown both downregulated expression of vimentin and active form of MMPs. d Using W7 (10 μm) and CaM knockdown significantly inhibited MMP2 activity detected by Gelatin zymography assay

Back to article page