Fig. 3: miR-143-3p inhibits GBC cell angiogenesis and proliferation in vivo. | Cell Death & Disease

Fig. 3: miR-143-3p inhibits GBC cell angiogenesis and proliferation in vivo.

From: miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma

Fig. 3

a Matrigel containing 20 U of heparin and NOZ cells transfected with Lv-miR-NC or Lv-miR-143-3p was subcutaneously implanted in 4−6-week-old male BALB/c athymic nude mice. After 7 days, the Matrigel plugs were removed and photographed. n = 5 per group. b H&E and CD31 staining of the Matrigel plug. Scale bar, 100 mm. c Quantification of the microvessel density (mm−2; n = 5; *P < 0.05; Student’s t test). d Representative examples of tumours formed in nude mice implanted with the indicated cells. e, f The tumour growth curves are summarized in the line chart. A statistical plot of the average tumour weights in the subcutaneous xenograft model (**P < 0.01, ***P < 0.001, n = 5)

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