Fig. 5: STK17B is a direct downstream target of miR-455-3p. | Cell Death & Disease

Fig. 5: STK17B is a direct downstream target of miR-455-3p.

From: STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma

Fig. 5

a The heat map of some differentially expressed genes under gene chips analysis. b Binding site of miR-455-3p in wild type 3′-UTR of STK17B and the corresponding mutant type. c Result of luciferase reporter assay. Luciferase activity of HEK293T transfected with wild type 3′-UTR was significantly suppressed by miR-455-3p overexpression. d, e Expression of STK17B was decreased or promoted on mRNA and protein level under the condition of miR-455-3p overexpression or silencing. f Relative expression of miR-455-3p in normal liver cell line L02 and HCC cell lines. All data are expressed as means ± SD of three separate experiments. **P < 0.01; ***P < 0.001

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