Fig. 6: miR-455-3p inhibits invasion and metastasis both in vitro and in vivo. | Cell Death & Disease

Fig. 6: miR-455-3p inhibits invasion and metastasis both in vitro and in vivo.

From: STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma

Fig. 6

a Representative images of wound-healing assay and corresponding statistical analysis. Overexpression of miR-455-3p markedly inhibited cell motility, while knockdown of miR-455-3p promoted cell motility. b Results of transwell assay indicated that invasion capacity can be suppressed by miR-455-3p overexpression and enhanced by miR-455-3p knockdown. c Representative images of lung metastasis were captured by Nikon camera. MiR-455-3p significantly inhibited lung metastasis. d Number of metastatic lung nodules in each group. e Representative images of H&E. H&E staining were carried out using lung metastasis sample. f The expression of E-cadherin, N-cadherin, and Vimentin was accessed by western blotting after overexpressing of silencing miR-455-3p. g Immunofluorescence analysis of E-cadherin and vimentin expression. The results are presented as mean ± SD from three independent experiments. **P < 0.01; ***P < 0.001

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