Fig. 1: Schematic diagram illustrating the heterogeneity in ex vivo cultured human islets (right) as opposed to the scenario expected in in vivo conditions in the pancreas where INS-secreting β cells (in blue) are predominant (left). | Cell Death & Disease

Fig. 1: Schematic diagram illustrating the heterogeneity in ex vivo cultured human islets (right) as opposed to the scenario expected in in vivo conditions in the pancreas where INS-secreting β cells (in blue) are predominant (left).

From: Heterogeneity and cell fate flux in single human pancreatic islet cells

Fig. 1

The heterogeneity in the isolated islets is characterized by the presence of INS-positive cells that also display expression of multihormonal transcripts, pancreatic progenitor genes, and/or exocrine genes. The de-differentiation signatures observed in these cells suggest that rare pancreatic cells are undergoing cell fate flux, which may have an impact on downstream islet cell function, in particular that of β cells. The population subtypes shown in this diagram are not meant to be mutually exclusive

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