Fig. 13: The schematic illustrates a model that long noncoding RNA MEG3 suppresses liver cancer cells growth through β-catenin by activating PKM2 and inactiviating PTEN. | Cell Death & Disease

Fig. 13: The schematic illustrates a model that long noncoding RNA MEG3 suppresses liver cancer cells growth through β-catenin by activating PKM2 and inactiviating PTEN.

From: Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN

Fig. 13

MEG3 promotes the expression and maturation of miR122 which targets PKM2. Therefore, MEG3 decreased PKM2 expression and nuclear location dependent on miR122. Furthermore, MEG3 inhibited CyclinD1 and C-Myc via PKM2 in liver cancer cells. Strikingly, MEG3 promotes β-catenin degradation through ubiquitin–proteasome system dependent on PTEN. Moreover, MEG3 inhibits β-catenin activity through PKM2 reduction and PTEN increase. Furthermore, we found that excessive β-catenin rescued the effect of MEG3 in liver cancer

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