Fig. 3: Increased apoptosis in Dcx+ cells but not in GFAP+ or MASH1+ cells in the SVZa of Hpx-null mice. | Cell Death & Disease

Fig. 3: Increased apoptosis in Dcx+ cells but not in GFAP+ or MASH1+ cells in the SVZa of Hpx-null mice.

From: Hemopexin is required for adult neurogenesis in the subventricular zone/olfactory bulb pathway

Fig. 3

a Every fifth coronal section from each brain was subjected to TUNEL (green) assay. Quantification of the total number of TUNEL-labeled cells showed a twofold increase in apoptosis in the SVZa of Hpx−/− mice. b–d Anti-GFAP (b, red), anti-MASH1 (c, red), or anti-Dcx (d, red) was used for co-labeling (arrowhead) with TUNEL to detect apoptosis in each type of neural stem cells/progenitors. More apoptosis was observed in Dcx+ cells but not in GFAP+ or MASH1+ cells. n = 5. **p < 0.01. Scale bar, 20 μm

Back to article page