Fig. 3: BRCA1 is a key DEG | Cell Death & Disease

Fig. 3: BRCA1 is a key DEG

From: Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

Fig. 3

. a The increase in the number of DMs in CPX1, CPX4, CPX5, and CPX6 for each group. n = 100 from three independent studies. b Quantitative real-time PCR results of relative mRNA expression of the genes in Table 1, n = 3. c Western blot results show decreases of Rad51, BRCA1, and Chk1 levels. d Quantification of the protein levels in c, n = 3. *P < 0.05; **P < 0.01; ***P < 0.001

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