Table 1 DSB-associated gene expression from RNA-seq data

From: Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts

Gene

Read count

p value

q value

Log2.Fold_change

 

C1

C2

   

BRCA1

56.15029303

27.91804213

0.00076613

0.010053

−1.0081

Chek1

24.362124

9.603806492

0.0062685

0.057512

−1.343

Rad51

57.55918695

22.03664125

1.75E−05

0.00037981

−1.3851

ATM

32.46326403

46.08338154

0.19742

0.67448

0.50544

ATR

37.86402405

28.14138646

0.1525

0.5796

−0.42813

BRCA2

17.75793376

10.90664846

0.15062

0.57492

−0.70326

Chek2

11.47661504

8.375412638

0.40965

0.96019

−0.45447

  1. Note: C1, CPX1; C2, CPX6; q value, the lower value, the more difference between C1 and C2; log 2.Fold_change, C2/C1; A significant difference is defined as P < 0.05
  2. DSB double-strand break, RNA-seq RNA-sequencing
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