Fig. 1: MSCs suppressed tumor formation in the Is of hepatocarcinoma development and promoted tumor development in the Ps.
From: The distinct roles of mesenchymal stem cells in the initial and progressive stage of hepatocarcinoma
a A diagram of experimental protocol. Rats were administrated DEN (100 p.p.m., 95 mg/L) in drinking water for 14 weeks. DEN + MSC (Is) group was transplanted MSCs (1 × 106) by intravenous injection at 4th, 6th, 8th week, and DEN + MSC (Ps) group was transplanted MSCs (1 × 106) as the same method at the 10th, 12th, 14th week, respectively. b Survival cures of DEN, DEN + MSC (Is) and DEN + MSC (Ps) groups. c, e Gross and H&E staining appearance of livers in DEN and DEN + MSC (Is) group at 14 weeks c or DEN and DEN + MSC (Ps) group at 16 weeks after DEN treatment e. Dashed lines indicate the tumor area. d, f Tumor incidence, max tumor volume, and ratio of liver/body weight of DEN and DEN + MSC (Is) group at 14th week d, or DEN and DEN + MSC (Ps) group at 16th week f. Values are shown as mean ± SEM (*P < 0.05, **P < 0.01). Representative of three independent experiments. The area in the dotted line was shown as tumor area. ns no significant difference
